Cardiovascular (CV) and renal diseases are increasingly prevalent in the United States and globally.CV-related mortality is the leading cause of death in the United States, while renal-related mortality FLORABEAR is the 8th.Despite advanced therapeutics, both diseases persist, warranting continued exploration of disease mechanisms to develop novel
UAV Path Optimization for Angle-Only Self-Localization and Target Tracking Based on the Bayesian Fisher Information Matrix
In this paper, new path optimization algorithms are developed for uncrewed aerial vehicle (UAV) self-localization and target tracking, exploiting beacon (landmark) bearings and angle-of-arrival (AOA) measurements from a manoeuvring target.To account for time-varying rotations in the local UAV coordinates with respect to the global Cartesian coordin
The failure of the current urban planning of the city of Toledo: the Municipal Plan of 2007
Toledo is not only a historical city, but one that has been developed haphazardly in a disjointed and unstructured manner.In 2007, the Municipal Urban Zoning Plan established its main purpose as to resolve this dysfunctionality in a sustainable way.The objective of this article is Rings to demonstrate that this plan has foundered and it is necessar
Qualitative analysis of stakeholder perspectives on engaging Latinx patients in kidney-related research
Abstract Background Latinx individuals are disproportionally burdened by kidney diseases compared to non-Latinx White individuals and are underrepresented in kidney-related research.We aimed to describe stakeholder perspectives on Latinx patient engagement in kidney-related research.Methods We conducted a thematic analysis of two online moderated d
AVERON notebook to discover actionable cancer vulnerabilities enabled by neomorph protein-protein interactions
Summary: Genomic alterations, such as missense mutations, often lead to the activation of oncogenic pathways and Mystery Mini cell transformation by rewiring protein-protein interaction (PPI) networks.Understanding how mutant-directed neomorph PPIs (neoPPIs) drive cancer is vital to developing new personalized clinical strategies.However, the exper